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Tonight
14 Oct - 15 Oct
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15 Oct - 16 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Lake Issaqueena hotels

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.
A hotel lobby with a long corridor, seating areas, and a reception desk.
A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".

1. The Inn at Patrick Square

The Inn at Patrick Square
9.2 km from Lake Issaqueena
United States
Jennifer
฿5,001
฿5,552 total
includes taxes & fees
18 Oct - 19 Oct
The Inn at Patrick Square
An outdoor patio area with a fire pit, seating, and string lights.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A food court with a beverage display, seating area, and a Clemson University sign.

2. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
5.8 km from Lake Issaqueena
United States
Melissa
฿3,572
฿3,929 total
includes taxes & fees
8 Nov - 9 Nov
Tru by Hilton Seneca Clemson
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

3. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
10.6 km from Lake Issaqueena
United States
Lori
฿4,027
฿4,430 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn & Suites Seneca Clemson Univ Area
A golf course with a water body, trees, and a distant view of a bridge.
A modern building with a central entrance, surrounded by a well-maintained lawn and trees.
An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

4. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
8.7 km from Lake Issaqueena
United States
Lilllian
฿5,001
฿5,552 total
includes taxes & fees
18 Oct - 19 Oct
Clemson University's James F. Martin Inn
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.
Private kitchen

5. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
15.8 km from Lake Issaqueena
United States
Sebastian
฿3,390
฿5,206 total
includes taxes & fees
12 Nov - 13 Nov
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A modern bar area with a menu board, bar stools, and a countertop with various items.
A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.
A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.
A modern dining area with a bar, bar stools, and a patterned rug.

6. Courtyard Marriott Clemson

Courtyard Marriott Clemson
7.3 km from Lake Issaqueena
United States
kim
฿3,733
฿4,143 total
includes taxes & fees
1 Nov - 2 Nov
Courtyard Marriott Clemson
A modern kitchen area with a bar counter and seating.
A vending area with snacks and beverages, including chips and soda.
A modern bar area with high stools and a poolside view.
A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.

7. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
5.5 km from Lake Issaqueena
United States
Blaise
฿3,681
฿4,085 total
includes taxes & fees
21 Oct - 22 Oct
Hampton Inn Clemson-University Area
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
An outdoor patio with wicker furniture, a round table, and a fountain.

8. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
6.7 km from Lake Issaqueena
United States
Laurrie
฿7,016
฿7,787 total
includes taxes & fees
18 Oct - 19 Oct
The Shepherd Hotel Downtown Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

9. The Abernathy of Clemson

The Abernathy of Clemson
6.7 km from Lake Issaqueena
United States
Amy
฿5,408
฿6,002 total
includes taxes & fees
26 Oct - 27 Oct
The Abernathy of Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

10. Lakeside Lodge Clemson

Lakeside Lodge Clemson
5.6 km from Lake Issaqueena
United States
Lori
฿3,659
฿4,542 total
includes taxes & fees
15 Oct - 16 Oct
Lakeside Lodge Clemson
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.
A conference room with a large round table, multiple chairs, and a projector.
A hotel breakfast area with a self-serve station, including a refrigerator, coffee machine, and fruit display.
A hotel room with a large bed, bedside tables, a desk with a chair, a TV, and a window with a view.

11. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
7.1 km from Lake Issaqueena
United States
John
฿4,330
฿4,806 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Clemson by IHG
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.

12. Inn @ Clemson

Inn @ Clemson
6.5 km from Lake Issaqueena
United States
Samantha
฿2,689
฿2,984 total
includes taxes & fees
18 Oct - 19 Oct
Inn @ Clemson
Room
A hotel reception area with two reception desks, a digital screen, and a tiled floor.
A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.
A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.

13. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
6.6 km from Lake Issaqueena
United States
Yvette
฿3,681
฿4,085 total
includes taxes & fees
4 Nov - 5 Nov
Comfort Inn & Suites Clemson - University Area
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.
A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.

14. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
6.8 km from Lake Issaqueena
United States
David
฿3,681
฿4,085 total
includes taxes & fees
18 Oct - 19 Oct
Best Western Plus Clemson Hotel & Conference Center
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

15. Quality Inn Seneca US-123

Quality Inn Seneca US-123
13.5 km from Lake Issaqueena
United States
Barry
฿2,622
฿3,089 total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.

16. Best Western Seneca-Clemson

Best Western Seneca-Clemson
9.7 km from Lake Issaqueena
United States
Michelle
฿3,424
฿3,766 total
includes taxes & fees
28 Oct - 29 Oct
Best Western Seneca-Clemson
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

17. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
8.6 km from Lake Issaqueena
United States
Lloyd
฿4,138
฿4,552 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn & Suites Seneca-Clemson Area
A swimming pool with lounge chairs and a covered area with tables and chairs.
A modern bedroom with a large bed, a ceiling fan, and a view of the outdoors through a window.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a microwave.
A spacious living room with a dark leather sofa, a wooden coffee table, and a dining area with a table and chairs. Large windows provide natural light and views of the outdoors.

18. Carolina Camp Cedar

Carolina Camp Cedar
20.2 km from Lake Issaqueena
United States
Katlynn
฿3,659
฿6,856 total
includes taxes & fees
15 Oct - 16 Oct
Carolina Camp Cedar
A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.
A hotel room with two beds, a desk, a chair, a TV, and a painting on the wall.
A reception desk with a vase of flowers, framed pictures, and a printer.
A gazebo with a tiled roof and wooden pillars, surrounded by a fence and potted plants.

19. Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
7.1 km from Lake Issaqueena
United States
David
฿2,689
฿2,984 total
includes taxes & fees
18 Oct - 19 Oct
Days Inn by Wyndham Clemson
A kitchen with a coffee maker, microwave, and refrigerator.
A hotel room with a large bed, a bedside table, a nightstand, and a wall-mounted lamp.
A red brick building with a white porch and columns, a door, and windows.
A reception area with a check-in desk, a seating area with a bench, and a wall-mounted display of postcards.

20. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
17.7 km from Lake Issaqueena
United States
Richard
฿2,425
฿2,704 total
includes taxes & fees
12 Nov - 13 Nov
Rodeway Inn & Suites Walhalla
View all properties

Compare popular hotels close to Lake Issaqueena

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
The Inn at Patrick Square
9.8
Exceptional
926 reviews
View
An outdoor patio area with a fire pit, seating, and string lights.
Tru by Hilton Seneca Clemson
9.2
Wonderful
899 reviews
View
A poolside area with outdoor seating and a view of a lake and forested hills.
Fairfield Inn & Suites Seneca Clemson Univ Area
9.4
Exceptional
284 reviews
View
A golf course with a water body, trees, and a distant view of a bridge.
Clemson University's James F. Martin Inn
9.4
Exceptional
1,005 reviews
View
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
9.8
Exceptional
112 reviews
View

Top Lake Issaqueena Hotel Reviews

Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent
"Let’s just say you will be pleasantly surprised how great a hotel this is. It is literally around the corner from Clemson University. The rooms ar"
George 1-night trip
Posted 5 hours ago
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"Everything was great. We really enjoyed it. We would definitely stay again"
Stephen 1-night trip
Posted 3 days ago
Tru by Hilton Seneca Clemson

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

8.6/10 (58 reviews)
Larry W. Abernathy Waterfront Park is just one of the places to see in Clemson, so why not enjoy the other things to explore during your travels? Experience the area's theatre scene or attend a football match.
See properties

Littlejohn Coliseum

9.4/10 (141 reviews)
Catch an event at Littlejohn Coliseum during your trip to Clemson. Amble around the area's lakeside or attend a football match.
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Sloan Tennis Center

Catch an event at Sloan Tennis Center during your trip to Clemson. You can attend a football match while in the area.
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Memorial Stadium

9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theatre scene or attend a football match.
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Clemson Area African American Museum

You can spend time exploring the galleries in Clemson Area African American Museum in Clemson. You can attend a football match while in the area.
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Wyndham Plaza

You can search for that perfect souvenir at Wyndham Plaza during your stay in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
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World of Energy

You can spend an afternoon browsing the exhibits at World of Energy in Seneca. Amble around this family-friendly area's lakeside or attend a sporting event.
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Frequently asked questions

What's the area like around Lake Issaqueena?
Lake Issaqueena is located in Central. You'll find 209 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Lake Issaqueena?
Lakeside Lodge Clemson is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. It's located 3.5 mi (5.6 km) from Lake Issaqueena. Other good choices within 5 miles include Best Western Plus Clemson Hotel & Conference Center and Comfort Inn & Suites Clemson - University Area.
How many hotels will I find close to Lake Issaqueena?
Expedia has 209 hotels and other accommodation options a few miles from Lake Issaqueena.
If I need to cancel the hotel reservation for my stay near Lake Issaqueena, will I receive a refund?
Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to get the top deals on offer near Lake Issaqueena.
What can I see and do near Lake Issaqueena?
You'll want to browse the exhibits at Fort Hill and Clemson Area African American Museum. Explore nature at Keowee Reservoir and Larry W. Abernathy Waterfront Park. If you've got some time to explore the area around Lake Issaqueena, you may want to make a stop by Littlejohn Coliseum, Memorial Stadium and Sloan Tennis Center.