A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Our top choices for Key Largo hotels with a spa

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Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,353 reviews)
  • cleanliness
    Luxury spa sanctuary with 7 treatment rooms offers beachside massages and tranquil gardens for ultimate rejuvenation.
The price is ฿8,003
฿11,452 total
includes taxes & fees
19 Jul - 20 Jul
Cheeca Lodge & Spa
Single Room | Terrace/patio

Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
2.5 star property
Rock Harbor
9.8 out of 10, Exceptional, (333 reviews)
  • cleanliness
    Serene spa getaway with tranquil gardens and sunset views from the oceanfront hot tub.
The price is ฿5,063
฿6,638 total
includes taxes & fees
21 Jul - 22 Jul
Kona Kai Resort and Gallery - Adults Only
Body treatments, aromatherapy, hot stone massages, deep-tissue massages

Reefhouse Resort & Marina

Reefhouse Resort & Marina
4.5 star property
Key Largo
9.4 out of 10, Exceptional, (1,501 reviews)
  • cleanliness
    Discover tranquil bliss at this waterfront haven with three spa rooms, private beach, and hot stone massages.
The price is ฿7,333
฿9,589 total
includes taxes & fees
27 Jul - 28 Jul
Reefhouse Resort & Marina
Reception

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
9.0 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Immerse in waterfront wellness at this bay resort with a full-service spa, offering daily Ayurvedic treatments and relaxing garden escapes.
The price is ฿9,342
฿12,356 total
includes taxes & fees
9 Aug - 10 Aug
Playa Largo Resort & Spa, Autograph Collection
In-room dining

Premium Floating Bungalow by Stay Ombi

Premium Floating Bungalow by Stay Ombi
3.5 star property
Key Largo
10.0 out of 10, Exceptional, (2 reviews)
  • cleanliness
    Luxurious massages offered on spa-equipped houseboat with premium floating rooms and serene water access.
The price is ฿25,993
฿29,242 total
includes taxes & fees
17 Jul - 18 Jul
Premium Floating Bungalow by Stay Ombi
Deep-tissue massages, Swedish massages, prenatal massages, massages

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.6 out of 10, Exceptional, (78 reviews)
  • cleanliness
    Beachfront spa villa with two pools, massage services, and scenic water walkway offers rejuvenating Florida escape.
The price is ฿16,709
฿20,644 total
includes taxes & fees
2 Aug - 3 Aug
The Islands of Islamorada
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Key Largo

Pool
Hot tub

Top Key Largo Hotel Reviews

Holiday Inn Key Largo by IHG

Holiday Inn Key Largo by IHG

10/10 Excellent
"We loved our stay at this hotel!!! The grounds are very pretty. The pool and Tiki bar and wonderful and the staff is really kind and friendly!!! The front desk was amazingly helpful as we requested to move rooms so we could be closer to the pool! The gym is small, but had everything we needed and was kept up well! We paid for breakfast and it was really good, especially with two teenagers!!! We were walking distance to two great waterside restaurants and close to the park to snorkel! We would for sure go back and highly recommend!!!"
Meg 4-night trip
Posted 4 hours ago
Holiday Inn Key Largo by IHG

Frequently asked questions

Looking for a spa hotel in Key Largo?
Forget the stress of everyday life and book yourself a hotel with a spa. Travellers love the sunsets in Key Largo. Discover the coral reefs and seafood restaurants during your stay. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your stay.
What is the best spa hotel in Key Largo?
Reefhouse Resort & Marina is a top beachfront spa hotel featuring 3 restaurants, a 24-hour fitness centre, a bar and an outdoor pool. Treat yourself to a facial, body scrub or detox wrap at Opal Spa. Another popular spa hotel in Key Largo is Playa Largo Resort & Spa, Autograph Collection.
How many spa hotels will I find in Key Largo?
Among Expedia's 1309 accommodation options in Key Largo, there are 2 spa hotels.
What's there to see and do in Key Largo?
Enjoy Key Largo and visit Everglades National Park, Jimmy Johnson's Big Chill and Jacob's Aquatic Center. If you have a bit of extra time while you're in the area, you might want to check out Bluefin Rock Harbor Marina and John Pennekamp Coral Reef State Park.
What is a Key Largo spa hotel?
Spa hotels in Key Largo provide lodging and have an on-site spa offering services such as facials and body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.