A historic stone fortress with a central dome and surrounding walls.

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Check availability on Colon Luxury Hotels

Tonight
7 Oct - 8 Oct
Tomorrow
8 Oct - 9 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Colon luxury hotels

A balcony with a table, chairs, and a view of a city skyline across a body of water.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

1. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
  • Indulge in colonial elegance at this Panama City gem featuring a full-service spa, outdoor pool, and gourmet dining.
฿11,800
฿12,980 total
includes taxes & fees
3 Nov - 4 Nov
Sofitel Legend Casco Viejo, Panama City
A poolside area with lounge chairs and a view of the ocean.
A terrace with seating and a view of the ocean.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.

2. JW Marriott Panama

JW Marriott Panama
San Francisco
  • Unwind in opulent waterfront luxury with 4 pristine pools and ocean-view dining in Panama City.
฿9,386
฿10,324 total
includes taxes & fees
31 Oct - 1 Nov
JW Marriott Panama
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.

3. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
  • Exclusive Panama City escape offers lavish poolside retreats and gourmet dining experiences.
฿4,436
฿4,879 total
includes taxes & fees
21 Oct - 22 Oct
Hotel Riu Plaza Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.
A modern interior with a spiral staircase, a large window, and a seating area.

4. Hilton Panama

Hilton Panama
Bella Vista
  • Panama City sophistication meets relaxation with an attached winery, poolside dining, and a full-service spa offering couples' treatments.
฿8,372
฿9,210 total
includes taxes & fees
6 Nov - 7 Nov
Hilton Panama
A restaurant with multiple dining tables, chairs, and a central water feature.
A bar area with multiple seating options, a bar counter, and a fireplace.
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.
A rooftop terrace with tables and chairs, a view of two white towers, and a building with a large window.

5. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
Casco Viejo
  • Experience historic luxury in Panama's Casco Viejo district with 5 restaurants and a rooftop pool with spectacular views.
฿8,830
฿9,712 total
includes taxes & fees
9 Oct - 10 Oct
Hotel La Compañía Casco Antiguo
A hotel entrance with a central water feature, seating areas, and potted plants.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
A pool with a central water feature, surrounded by seating areas and potted plants.

6. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
  • Elevate your Panama City escape with a Jack Nicklaus golf course, rejuvenating spa treatments, and poolside luxury at this 5-star retreat.
฿9,304
฿10,234 total
includes taxes & fees
1 Nov - 2 Nov
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.

7. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
  • Panama City elegance at this Waldorf Astoria hotel with a full-service spa, outdoor pool, and refined dining in two upscale restaurants.
฿8,830
฿9,712 total
includes taxes & fees
6 Nov - 7 Nov
Waldorf Astoria Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A modern interior with a central seating area, potted plants, and a staircase.
A spacious hotel lobby with modern furniture, large windows, and a city view.
A modern building with a sign reading 'HYATT REGENCY.'

8. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
  • Indulgence awaits in this 4.5-star Panama City sanctuary featuring a full-service spa, outdoor pool, and elegant dining near Via Espana.
฿6,286
฿6,915 total
includes taxes & fees
17 Oct - 18 Oct
Hyatt Regency Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.

9. W Panama

W Panama
Bella Vista
  • Lavish urban retreat offers 3 hot tubs, poolside luxury, and concierge services in Panama city.
฿7,772
฿8,549 total
includes taxes & fees
1 Nov - 2 Nov
W Panama
A hotel room with a bed, a desk, a chair, and a nightstand.
A modern spa area with a hot tub, seating, and a city view.
A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
A rooftop lounge with modern seating and a panoramic city view.

10. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
  • Experience luxury and elegance in a Panamanian retreat with 2 restaurants, a spa, and casino.
฿5,071
฿5,578 total
includes taxes & fees
31 Oct - 1 Nov
Megapolis Hotel Panamá
View all properties

Top Colon Hotel Reviews

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

10/10 Excellent
"Todo salio increíble"
Ana Ligia 2-night trip
Posted 19 hours ago
Courtyard by Marriott Panama Multiplaza Mall
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Over all stay was amazing ‼️‼️ very clean areas and very helpful staff . Breakfast had so many varieties and tasted fresh and delicious. I will definitely be returning ."
Shandice Iesha L 7-night trip
Posted 19 hours ago
Hotel Riu Plaza Panama
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

10/10 Excellent
"Excellent stay"
David 1-night trip
Posted 1 day ago
Gamboa Rainforest Reserve
Decapolis Hotel Panama City

Decapolis Hotel Panama City

10/10 Excellent
"Bueno"
Enimer 5-night trip
Posted 1 day ago
Decapolis Hotel Panama City
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

10/10 Excellent
"Muy buena ubicación, habitaciones limpias y espaciosas. Bar abierto hasta las 11pm"
Manuel 1-night trip
Posted 2 days ago
Las Americas Golden Tower Panama
Hotel Ojos del Rio

Hotel Ojos del Rio

8/10 Good
"No hot water in the shower."
charles 2-night trip
Posted 8 days ago
Hotel Ojos del Rio

Frequently asked questions

Are you looking for a luxury hotel for your Colon holiday?
Use Expedia to arrange your flight to Panama City (PAC-Marcos A. Gelabert Intl.) airport or Balboa (BLB-Panama Pacifico Intl.) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Colon offers. Colon has some interesting things to see and do including Colon 2000 and Colon Free Zone, so you might want to take in the local sights during your visit.
What's the best luxury place to stay in Colon?
Sand Diamond Hotel is a luxury hotel with ski-in/ski-out access and a casino, and it's a popular choice for Expedia travellers looking for an elegant place to stay.
When can I expect good weather in Colon?
Planning for the weather is an important factor for making your trip to Colon a success, especially when you're splurging. The hottest months are usually May and September, with an average temperature of 27°C, while the coldest months are January and February, with an average of 26°C. The rainiest months in Colon are November, July, August and October, with each month seeing an average of 350 mm of rainfall.
What's there to see and do in Colon?
Take in the sights and attractions that Colon offers with a visit to Colon 2000, Colon Free Zone and Gamboa Rainforest Resort. If you have extra time while you're in the area, you might want to see Fantastic Casino | Colón 2000 and Fort San Lorenzo.
How can I get around Colon?
It's easier to get around town in style when you know your options. If you want to venture outside the area, hop aboard a train at Colon Atlantic Passenger Station.