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Find hotels in Cairo, IL from ฿2,115

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Our top choices for Cairo hotels

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (291 reviews)
"Breakfast was sparse. This motel needs a complete overhaul. "
United States
Susan
The price is ฿2,265
฿2,514 total
includes taxes & fees
31 Jul - 1 Aug
Quality Inn Cairo I-57

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (648 reviews)
"Clean rooms,"
United States
Karl
The price is ฿1,993
฿2,211 total
includes taxes & fees
19 Jul - 20 Jul
Super 8 by Wyndham Charleston/Sikeston East MO

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (420 reviews)
"Staff was excellent. It was fine for what it was — a cheap place near the highway"
United States
Emily
The price is ฿2,385
฿2,647 total
includes taxes & fees
19 Jul - 20 Jul
The Riverstone Hotel Charleston-Sikeston

La Center Motel

La Center Motel
2.0 star property
La Center
7.4 out of 10, Good, (20 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
The price is ฿1,808
฿2,115 total
includes taxes & fees
18 Jul - 19 Jul
La Center Motel

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is ฿2,320
฿2,575 total
includes taxes & fees
9 Aug - 10 Aug
Eagle Inn Charleston

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ฿4,989
฿9,727 total
includes taxes & fees
15 Aug - 16 Aug
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

More cheap stays in Cairo

Find out more about Cairo

Top reasons to visit Cairo

  • Scenic Riverboat Tours: Experience the beauty of Cairo's waterways with unique riverboat tours that offer stunning views.
  • Outdoor Adventures: Enjoy camping and exploring various national and state parks, perfect for nature enthusiasts.
  • Historical Charm: Discover the rich heritage of Cairo through its historic forts and charming streets.
  • Family-Friendly Atmosphere: Enjoy a welcoming environment with activities suitable for families and visitors of all ages.
  • Diverse Accommodation Options: Choose from a range of lodgings, from charming inns to comfortable motels, catering to every traveller's needs.

Find great hotels in and around Cairo

Whether you're seeking a family-friendly hotel, a pet-friendly inn, or a comfortable motel for your business trip, Cairo, Illinois, offers a variety of accommodation options to suit every traveller's needs. From charming agritourism properties to well-equipped hotels, you can enjoy a memorable stay in this unique destination. Explore the best hotels in Cairo and find the perfect base for your American adventure.

  • Super 8 by Wyndham Charleston/Sikeston East MO: This budget-friendly motel offers a welcoming atmosphere for families and pet owners alike, located 16km from Cairo. Super 8 is known for its family-oriented amenities, including complimentary cribs upon reservation, making it an ideal choice for those travelling with young children. The property also accommodates pets, ensuring your furry friends are part of the adventure. Guests appreciate the warm hospitality and essential comforts that make for a pleasant stay.
  • The Riverstone Hotel Charleston-Sikeston: Situated 19km from Cairo, The Riverstone Hotel is an economical option catering to business travellers and pets. This hotel features comprehensive amenities for those on work trips, alongside welcoming policies for pets, including weight restrictions and a pet deposit. The ambiance strikes a balance between functionality and comfort, appealing to both business and leisure guests. Its proximity to local business hubs makes it a convenient choice for professionals seeking a comfortable stay.
  • Quality Inn Cairo I-57: Located right within Cairo, Quality Inn offers a family-friendly environment ideal for those travelling with children and pets. The hotel provides essential amenities such as a first aid kit and free cribs, enhancing the comfort for families. With policies that permit pets, including dogs, guests can enjoy peace of mind knowing their furry companions are welcome. The inviting atmosphere and convenient location make it a solid choice for a relaxing getaway.

Where to stay near Cairo

Cairo, Illinois offers a delightful blend of outdoor adventures and historical charm. Explore the scenic streets of Cairo, where family-friendly vibes mingle with local culture. Enjoy holidays filled with activities in the surrounding areas, and discover inviting campgrounds perfect for relaxation. Immerse yourself in the warm atmosphere created by the friendly residents, making your stay in this unique city an unforgettable experience.

  • Wickliffe: Located a mere 10km from Cairo, Wickliffe offers a charming escape for those seeking outdoor adventures and picturesque scenery. This city is ideal for a romantic getaway, with recreational areas and golf courses providing ample opportunities for leisure activities. Visitors can explore the nearby lake and national state park, where lush forests and tranquil waters create a perfect backdrop for relaxation or exploration. The consistent visitor numbers throughout the year ensure a welcoming atmosphere, especially during peak times in March to April and August.
  • Mound City: Also situated 10km from Cairo, Mound City is a delightful destination for adventure seekers and couples alike. Known for its vibrant outdoor scene, the city boasts recreational parks and golf facilities that cater to all ages. With a backdrop of forests and lakes, Mound City invites visitors to immerse themselves in nature. The peak travel months in March, July, and October offer a lively atmosphere, making it an excellent time to experience local events and activities. Discover the captivating urban parks that enhance the city’s charm.
  • Wyatt: Just 11km from Cairo, Wyatt is a family-friendly city that combines outdoor fun with a lively urban vibe. Popular for golf enthusiasts and pet lovers alike, the city features golf courses and dog parks that cater to varied interests. Wyatt’s local parks and event venues provide excellent spaces for family gatherings and community events. Though visitor numbers peak in the summer months of June to August, Wyatt’s welcoming spirit is present year-round, ensuring a delightful experience for all who visit.

Things to do in Cairo

Shopping

Cairo offers unique shopping experiences at local boutiques and shops along its main streets. If you're up for a drive, head to the nearby Cape Girardeau, where you can explore the West Park Mall for a variety of retail options, including fashion and electronics.

Recreation

Explore the serene landscapes at Fort Defiance State Park, where you can enjoy leisurely walks and picnics by the confluence of the Mississippi and Ohio Rivers. For a unique experience, consider a visit to the local yoga studios, offering classes that enhance relaxation and mindfulness amidst a tranquil setting.

Adventure

Cairo's historic riverfront offers scenic views and opportunities for fishing and kayaking along the confluence of the Mississippi and Ohio Rivers. Explore the nearby Shawnee National Forest for hiking trails, rock climbing, and mountain biking, immersing yourself in the diverse landscapes of southern Illinois.

Nightlife

Cairo offers a unique nightlife scene with venues like The Riverfront Grill, where you can enjoy live music while overlooking the riverside. For a more laid-back vibe, the local bars provide a friendly atmosphere to unwind after a day of exploring.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in and around Cairo

Cairo, Illinois, is ideal for those seeking outdoor adventures and scenic experiences. Visitors can explore a variety of attractions, including national and state parks, nature reserves, and historic forts. These points of interest offer a delightful blend of culture and nature, making it a perfect destination for travellers looking to immerse themselves in the area's rich heritage and natural beauty.

  • Columbus-Belmont State Park: Located 27km from Cairo, this park offers stunning outdoor scenery and a chance for adventure. Visitors can explore its trails, enjoy picnics, and take in the views of the Mississippi River, making it a pleasant retreat for nature lovers.
  • Ballard Wildlife Management Area: Situated 8km from Cairo, this wildlife preserve is a haven for birdwatchers and history enthusiasts alike. The area’s rich natural surroundings provide a budget-friendly opportunity to appreciate local wildlife and learn about the region's historical significance.
  • Fort Defiance State Park: Nestled within Cairo, this historic fort offers cultural insights into the area's past. Visitors can stroll through the park to appreciate its historical markers and scenic vistas where the Ohio and Mississippi Rivers converge.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Accessing Cairo, Illinois, is convenient through several nearby airports. Cape Girardeau Municipal Airport (CGI) is located 42km away, with hotels like Drury Plaza Hotel Cape Girardeau Conference Center and Courtyard by Marriott Cape Girardeau Downtown just 10km from the airport. Paducah Regional Airport (PAH) is 37km away, featuring options such as The Respite Bed and Breakfast, located 14km from the airport. For those flying into Veterans Airport of Southern Illinois (MWA), situated 84km from Cairo, Drury Inn & Suites Marion is a mere 3km away, offering easy access to guests. Each airport has various transport services to facilitate your journey.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 28 hotels and other accommodation options in the surrounding area. Find out more about Cairo.
What should I do while I'm visiting Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Take a look at what more there is to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.

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