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Go beyond your typical stay in Santa Ana

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Check prices for these dates

Tonight
5 Nov - 6 Nov
Tomorrow
6 Nov - 7 Nov
This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Santa Ana hotels

A hotel room with a bed, a sofa, a desk with a laptop, a painting on the wall, and a view of greenery outside.

1. La Gloria Hotel by BespokeColombia

La Gloria Hotel by BespokeColombia
3.5 star property
Mompos
9.6 out of 10, Exceptional, (50 reviews)
"Great hotel."
United States
Manuel
The price is ฿4,733
฿4,733 total
6 Nov - 7 Nov
La Gloria Hotel by BespokeColombia
A courtyard with two rocking chairs, surrounded by lush tropical plants and a traditional building with a tiled roof.

2. La Casa Amarilla

La Casa Amarilla
3.0 star property
Mompos
8.8 out of 10, Excellent, (53 reviews)
"Very nice hotel"
Mexico
Jorge
The price is ฿2,696
฿2,696 total
6 Nov - 7 Nov
La Casa Amarilla
A covered outdoor area with a wooden door leading inside, a tiled floor, and two rocking chairs with potted plants.

3. Hotel Palmas del Rio Mompox

Hotel Palmas del Rio Mompox
3.0 star property
Mompos
9.0 out of 10, Wonderful, (2 reviews)
"The room was impeccable and the staff was friendly, they went out of their way to help us. We did not give the hotel a five because our bathroom lacked a shower head and the hotel did not had any shampoo in our room. Otherwise everything went well. The breakfast was delicious and the staff was very welcoming. Will definitely stay there again."
United States
Saul
The price is ฿1,460
฿1,460 total
6 Nov - 7 Nov
Hotel Palmas del Rio Mompox
A corridor with brick columns, tiled flooring, and potted ferns.

4. LITERATIUM

LITERATIUM
3.0 star property
Mompos
9.4 out of 10, Exceptional, (16 reviews)
"Lovely stay, excellent staff, calm environment, and good breakfast :)"
Canada
Jennifer
The price is ฿3,547
฿3,547 total
7 Nov - 8 Nov
LITERATIUM
Interior detail

5. Karakalí Boutique Hotel

Karakalí Boutique Hotel
3.0 star property
Mompos
9.8 out of 10, Exceptional, (10 reviews)
"Great hotel, fresh and well done basic breakfast. Clea , comfortable rooms I truly recommend the hotel"
United States
Jorge
The price is ฿4,606
฿4,606 total
8 Nov - 9 Nov
Karakalí Boutique Hotel
A cozy restaurant interior with wicker furniture, a chandelier, and a sign reading "MOMPÓJ RESTAURANTE".

6. Bioma Boutique Hotel

Bioma Boutique Hotel
3.0 star property
Mompos
9.4 out of 10, Exceptional, (62 reviews)
"Great room, very attentive and helpful staff, excellent location, spotless rooms, incredible breakfast"
Australia
Daniel
The price is ฿2,721
฿2,721 total
9 Nov - 10 Nov
Bioma Boutique Hotel
A bedroom with a large bed, a wooden ceiling, a balcony with a door, and a painting on the wall.

7. Hotel Casa Isabelita

Hotel Casa Isabelita
3.0 star property
Mompos
9.2 out of 10, Wonderful, (5 reviews)
"Lovely place. Near the old church"
United States
Danial
The price is ฿2,101
฿2,101 total
6 Nov - 7 Nov
Hotel Casa Isabelita
A hallway with a wooden bench, a potted plant, and a view of a lake.

8. San Rafael

San Rafael
3.5 star property
Mompos
9.8 out of 10, Exceptional, (25 reviews)
"Very good hotel, staff is great and well located"
United States
Richard
The price is ฿5,305
฿5,305 total
6 Nov - 7 Nov
San Rafael
A courtyard with a brick wall, a stone water feature, potted plants, and outdoor furniture.

9. Albarrada Hotel Boutique

Albarrada Hotel Boutique
3.0 star property
Mompos
10.0 out of 10, Exceptional, (3 reviews)
"🌟🌟🌟🌟🌟 Me hospedé varios días en el Albarrada Hotel Boutique y mi experiencia fue excepcional. Desde el primer momento, el servicio fue muy profesional y cercano. Quiero destacar especialmente a Miquel en la recepción, quien cada noche me sorprendía con un gesto inolvidable: sabía que me gustaba el té y siempre me preparaba una taza al verme llegar. Ese detalle tan personal me impresionó y me hizo sentir como en casa. La habitación estaba impecable, con una cama tan cómoda que invitaba a...
United States
Maria
The price is ฿2,528
฿2,528 total
9 Nov - 10 Nov
Albarrada Hotel Boutique
A dining area with wooden chairs and a table, a brick wall with a mural, and a window with bars.

10. Hotel Archangelus

Hotel Archangelus
3.0 star property
Mompos
10.0 out of 10, Exceptional, (1 review)
"Absolutely delightful! The staff were helpful and pleasant, the room was well appointed, and the breakfast served was delicious. This was my favorite accommodation during my week in Colombia and I highly recommend it."
United States
Andrea
The price is ฿2,340
฿4,941 total
8 Nov - 9 Nov
Hotel Archangelus
A covered patio area with wooden pillars, terracotta tiles, and potted plants.

11. Hotel Boutique Casa Gerar Filigrana

Hotel Boutique Casa Gerar Filigrana
3.0 star property
Mompos
The price is ฿2,799
฿2,799 total
12 Nov - 13 Nov
Hotel Boutique Casa Gerar Filigrana
A room with two single beds, a mirror, an air conditioning unit, and a door.

12. Hotel Casa Evan

Hotel Casa Evan
2.0 star property
Mompos
8.0 out of 10, Very good, (1 review)
The price is ฿1,938
฿1,938 total
6 Nov - 7 Nov
Hotel Casa Evan
A covered corridor with potted plants, wooden columns, and a sign indicating a restaurant.

13. BOHEMIA HOTEL BOUTIQUE

BOHEMIA HOTEL BOUTIQUE
2.5 star property
Mompos
6.0 out of 10, (2 reviews)
"Muy buenas instalaciones. El servicio fue perfecto desde la Gerente del hotel, Lina, como Daniela y Don Juan. Muchas gracias por el servicio"
Colombia
Juan Pablo
The price is ฿3,692
฿3,692 total
6 Nov - 7 Nov
BOHEMIA HOTEL BOUTIQUE
A hotel with a sign reading "HOTEL SANTA BARBARA" and a contact number.

14. Hotel Santa Bárbara Mompox

Hotel Santa Bárbara Mompox
2.0 star property
Mompos
The price is ฿1,872
฿1,872 total
9 Nov - 10 Nov
Hotel Santa Bárbara Mompox
A balcony with a white balustrade overlooking a swimming pool and palm trees.

15. LA CANDELARIA ROOM HOUSE

LA CANDELARIA ROOM HOUSE
3.0 star property
Magangué
2.0 out of 10, (1 review)
"🚫 Terrible Experience – Do Not Stay Here I had one of the worst hotel experiences ever. The room was dirty, the bed was dirty, and the sheets looked like they had been used by previous guests without being changed. When I complained about the conditions, the owner/manager Javier Echeverría told me to leave immediately if I didn’t like the hotel. This was shocking, especially since my reservation had already been fully prepaid. The next morning, I checked out early even though I had paid for...
United States
Maria
LA CANDELARIA ROOM HOUSE
A two-story building with a balcony, a sign indicating a hotel, and a staircase leading to the entrance.

16. Hotel Jardines Evans By Geh Suites

Hotel Jardines Evans By Geh Suites
3.0 star property
Mompos
6.0 out of 10, (3 reviews)
"Being 7 days in this hotel in beautiful Mompox was a great time. It is a traditional building with practical rooms and enough places to sit and socialize. There is a restaurant for breakfast and other good meals and to drink and meet other people. The people of the hotel are great, friendly and helpful. Mompox is rather small, staying 3 days is enough to see most of the town and around. I preferred to stay longer, because it is a good place to recover from earlier activities or to get ready for...
Germany
Marc
The price is ฿3,254
฿3,254 total
19 Nov - 20 Nov
Hotel Jardines Evans By Geh Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Ana attractions

Puente Santa Ana - Talaigua Nuevo

After visiting Puente Santa Ana - Talaigua Nuevo, make a plan to see the other sights and activities in Santa Ana.
See properties

Top Santa Ana Hotel Reviews

A hotel room with a bed, a sofa, a desk with a laptop, a painting on the wall, and a view of greenery outside.
La Gloria Hotel by BespokeColombia

La Gloria Hotel by BespokeColombia

La Gloria Hotel by BespokeColombia
Mompos

10/10 Excellent

Fantastic! Wonderful staff. Great bedroom. Clean, spacious, comfortable.
United Kingdom
Carlos
Reviewed February 6, 2026
La Gloria Hotel by BespokeColombia

Frequently Asked Questions

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Ana.

What's it like to stay in Santa Ana?

Visitors will definitely enjoy all that Santa Ana has to offer. There are 32 hotels and other accommodation options in the surrounding area. Find out more about Santa Ana.

What should I do while I'm visiting Santa Ana?

A favourite place to visit is Magdalena River. You'll also find Te Deum House and Bolívar Stone in the area. Take a look at what more there is to see and do in Expedia's Santa Ana guide.

What's the seasonal weather like in Santa Ana?

The hottest months are usually February and March, with an average temperature of 29°C, while the coldest months are November and December, with an average of 27°C. The rainiest months in Santa Ana are May, August, October and September, with each month seeing an average of 346 mm of rainfall.

Where is the best place to stay in Santa Ana?

BOHEMIA HOTEL BOUTIQUE , located 18.1 mi (29.1 km) from the heart of Santa Ana, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hotel Palmas del Rio Mompox and Hotel Rio Grande. See all available top hotels, or vacation rentals in Santa Ana.