Find hotels in San Cosme y Damian from ฿1,882

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24 Dec - 25 Dec
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25 Dec - 26 Dec
This weekend
26 Dec - 28 Dec
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2 Jan - 4 Jan

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Stay near popular San Cosme y Damian attractions

Buenaventura Suarez Planetarium

You can spend time exploring the galleries in Buenaventura Suarez Planetarium in San Cosme y Damian. Take in the museums while you're in the area.
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Guarani Jesuit Ruins of San Cosme and San Damián

Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area.
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Top San Cosme y Damian Hotel Reviews

More cheap stays in San Cosme y Damian

Puesta del Sol by Nobile

Puesta del Sol by Nobile

14 de Mayo 44 Esq. Av. Francia Encarnacion Itapua
The price is ฿1,711 per night from 22 Jan to 23 Jan
฿1,711
฿1,882 total
22 Jan - 23 Jan 2026
includes taxes & fees
8.6/10 Excellent! (48 reviews)

Frequently asked questions

If I need to cancel my hotel reservation in San Cosme y Damian, will I receive a refund?
Yes! Most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Cosme y Damian.
What is there to see in San Cosme y Damian?
A couple of favourite places to visit are Buenaventura Suarez Planetarium and Guarani Jesuit Ruins of San Cosme and San Damián. Take a look at what more there is to see and do in Expedia's San Cosme y Damian guide.
What's the seasonal weather in San Cosme y Damian?
The hottest months are usually January and February, with an average temperature of 26°C, while the coldest months are July and June, with an average of 17°C. The rainiest months in San Cosme y Damian are October, November, May and April, with each month seeing an average of 198 mm of rainfall.