Pamplico Holiday Rentals, South Carolina: Private House Rentals

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Pamplico

Pet friendly

Apartment

Pool

Condo

Family friendly

Waterpark

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Pamplico hotels

An outdoor patio area with tables and chairs, a brick wall, and a glass door leading to the interior.

A spacious living room with hardwood flooring, a staircase, and a large window.

A spacious lobby with a grand staircase, plush seating, and a modern kitchen area.

A spacious dining area with multiple tables and chairs, wooden flooring, and a modern chandelier.

1. The Inn at the Crossroads

Lake City

Paige

฿3,749

฿4,199 total

includes taxes & fees

11 Nov - 12 Nov

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.

A multi-story hotel with a modern facade, featuring a prominent 'Hyatt Place' sign on the right.

A modern bar area with a long counter, bar stools, and a variety of bottles and glasses.

2. Hyatt Place Florence Downtown

Florence

Shanti

฿3,363

฿3,767 total

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with a chandelier, seating area, and a reception desk.

A spacious lobby with a chandelier, sofas, a reception desk, and a large window.

A conference room with a dark table and chairs, a vase with white flowers, and large windows with white trim.

A hotel room with a bed, a sofa, a desk, and a chair.

3. Quality Inn & Suites Lake City

Lake City

Vajannise

฿3,522

฿3,945 total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with two beds, a desk with a TV, and a bathroom visible through an open door.

A hotel lobby with a reception desk, seating area, and artwork on the walls.

A large, two-story building with a central entrance flanked by columns, labeled "DIR FRANK B. LEE NURSING BUILDING."

An outdoor patio area with brick walls, a fire pit, and outdoor seating.

4. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

Florence

Christopher

฿4,103

฿4,928 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a large seating area, a decorative ceiling light, and a view of the outdoors.

A brick building with a stone pillar, large potted plants, and a wreath on the door.

A living room with a sofa, chairs, a coffee table, a cabinet, and decorative items.

A hotel room with two beds, a desk, a chair, and a sofa.

5. Days Inn by Wyndham Lake City

Lake City

BRIANNA

฿3,316

฿3,714 total

includes taxes & fees

21 Oct - 22 Oct

A hotel lobby with a reception desk, seating area, and a television screen.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

A hotel room with a sectional sofa, two ottomans, a bed with a green bedspread, and framed pictures on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a flat-screen TV mounted on the wall.

6. Comfort Inn & Suites Florence Center Area

Florence

Mila

฿3,392

฿3,799 total

includes taxes & fees

3 Nov - 4 Nov

A hotel entrance with a stone facade, glass doors, and a number '501' above.

A corner market with shelves stocked with snacks and beverages, and two large refrigerators.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

An indoor swimming pool with a tiled floor, a pool ladder, and lounge chairs.

7. Fairfield Inn & Suites by Marriott Florence I-20

Florence

฿3,974

฿4,450 total

includes taxes & fees

25 Oct - 26 Oct

A restaurant with brick walls, framed awards, and a bar area.

An outdoor patio area with a brick wall, a covered seating area with string lights, and potted plants.

A bar area with a curved counter, multiple stools, and a brick wall backdrop.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

8. Hotel Florence, Tapestry Collection by Hilton

Florence

Ankh

฿3,978

฿4,455 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a wooden headboard, a window with curtains, and a wall-mounted air conditioner.

A modern kitchen with a built-in coffee station, a refrigerator, and a seating area with a patterned rug.

An indoor swimming pool with clear blue water, surrounded by green chairs and a tiled floor.

9. SpringHill Suites by Marriott Florence

Florence

John

฿3,483

฿4,101 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with wicker furniture, a wooden pergola, and a barbecue setup.

A modern kitchen with dark wood cabinets, a central island with a glass enclosure, and a white countertop.

A modern lounge area with a fireplace, comfortable seating, and a decorative wall.

A hotel with a sign reading "Homewood Suites Hilton" and a landscaped entrance area with a circular brick pathway and benches.

10. Homewood Suites by Hilton Florence

Florence

Aekyung

฿3,545

฿4,303 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A modern living room with a grey sofa, a flat-screen TV, geometric wall art, and a bookshelf with decorative items.

A hotel room with a large bed, a desk with a lamp, a chair, a TV, and a window with curtains.

A modern kitchen with a patterned backsplash, wooden cabinets, and stainless steel appliances.

11. Park Inn by Radisson Florence, SC

Florence

Juan

฿2,994

฿3,354 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a reception desk, seating area with patterned chairs, and a coffee station.

A hotel room with a bed, a desk, a green sofa, and a painting on the wall.

A hotel room with a desk, a green armchair, a small purple ottoman, a bed with a white headboard, and a large window.

12. Home2 Suites by Hilton Florence, SC

Florence

saleh

฿3,710

฿4,356 total

includes taxes & fees

3 Nov - 4 Nov

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

A modern lounge area with a sofa, armchairs, and small tables.

A reception area with a wooden desk, a map on the wall, and a sign welcoming visitors to Florence, SC.

A modern hotel room with a kitchenette, a grey sofa, a dining area, and a sign that reads "A Great Day Starts With Breakfast."

13. TownePlace Suites by Marriott Florence

Florence

Crystal

฿3,688

฿4,130 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a desk with a chair, a television, and a walk-in closet.

A snack and beverage display area with shelves stocked with various brands and a refrigerator with beverages.

A reception area with a modern design, featuring a reception desk, a digital display, and a sign for Holiday Inn Express & Suites.

A coffee station with two coffee machines and a display of coffee pods and cups.

14. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Florence

Leigh

฿3,834

฿4,294 total

includes taxes & fees

18 Oct - 19 Oct

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker. There is a dining area with two red chairs and a table.

A hotel room with a sofa, a dining table, a coffee maker, a TV, and artwork on the wall.

A hotel room with a bed, a desk, a TV, a refrigerator, and a painting on the wall.

A conference room with round tables, chairs, and a carpeted floor.

15. Staybridge Suites Florence - Civic Center by IHG

Florence

Tishia

฿4,540

฿5,085 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A vending area with snack and drink options, including Pepsi refrigerators and a 'MARKET' display with various products.

A spacious dining area with multiple tables and chairs, large windows offering a view of the parking lot, and a television mounted on the wall.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

16. Howard Johnson by Wyndham Florence

Florence

HOMERO

฿2,166

฿2,426 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a high ceiling, a central seating area with armchairs and a coffee table, a flat-screen TV, and a dining area with tables and chairs.

A modern hotel lobby with a central seating area, a large abstract painting, and a patterned carpet.

A spacious lobby with a large seating area, a flat-screen TV, and a fireplace.

A modern hotel lobby with a fireplace, seating area, and a reception desk.

17. Residence Inn Marriott Florence

Florence

Teri

฿3,740

฿4,189 total

includes taxes & fees

1 Nov - 2 Nov

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

A lobby with a fireplace, seating area, and a television.

A hotel room with two beds, a desk, a TV, and a window with patterned curtains.

A hotel lobby with a reception desk, seating area, and a welcome mat.

18. Hampton Inn & Suites Florence Center

Florence

Ryan

฿3,831

฿4,290 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a reception desk, seating area, and large windows.

An indoor swimming pool with clear poolside areas, a lifeguard station, and a view of the outside.

A Hilton Garden Inn with a large, multi-story building, a covered entrance, and a parking lot.

A reception area with a counter, a sign for 'The Pavilion Pantry', and a green wall.

19. Hilton Garden Inn Florence

Florence

Derrick

฿3,974

฿4,450 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with a fire pit, cushioned seating, and a pergola with string lights.

A modern hotel with a prominent 'TRU by Hilton' sign, a well-lit entrance, and a landscaped front yard.

A modern lounge area with seating, tables, and a pool table.

A snack kiosk with a variety of snacks and beverages, a sign for a 24/7 market, and a sign for local items.

20. Tru by Hilton Florence I-95

Florence

Tiffany

฿3,402

฿4,010 total

includes taxes & fees

19 Oct - 20 Oct

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Pamplico Hotel Reviews

Park Inn by Radisson Florence, SC

8/10 Good

"The room was clean, the pillows were small, the air conditioning unit was quiet , the bed was comfortable, the shower was spacious, the water press was good No complaints, everything was in working order and decent condition"

The Inn at the Crossroads

8/10 Good

"The room was nice ok not spectacular. The bed was way way too soft. The rooms does not have microwave ovens. And I had no choice this time so I stayed there. It was on the weekend nearly $300 that room was not worth $300. Next time I will plan better and stay in Florence. $600 for two rooms for 1 nights. I will not book again. The front desk employee was very pleasant."

Quality Inn & Suites Florence Civic Center

8/10 Good

"Very helpful staff! Great! Some of the exterior is showing age, but overall, a great value and easy location. The room was nice and roomy and very clean."

Hyatt Place Florence Downtown

10/10 Excellent

"Sage and clean"

Super 8 by Wyndham Florence

8/10 Good

"."

Comfort Inn & Suites Florence Center Area

10/10 Excellent

"The Comfort Inn in Florence SC was well a kept place to stay with professional service and a very nice breakfast set up. We were happy with the choice we made by staying at Comfort Inn in Florence SC."

Howard Johnson by Wyndham Florence

10/10 Excellent

"Excellent hotel! Will stay again."

Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

8/10 Good

"Good"

Aloft by Marriott Florence

8/10 Good

"Room was clean. Staff was helpful."

More cheap stays in Pamplico

Howard Johnson by Wyndham Florence

2038 W Lucas Street Florence SC

฿2,166

฿2,426 total

18 Oct - 19 Oct

includes taxes & fees

8.6/10 Excellent! (2,737 reviews)

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence SC

฿2,186

฿2,448 total

15 Oct - 16 Oct

includes taxes & fees

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC

฿2,957

฿3,312 total

19 Oct - 20 Oct

includes taxes & fees

8.4/10 Very good! (391 reviews)

Park Inn by Radisson Florence, SC

1729 Mandeville Road Florence SC

฿2,994

฿3,354 total

18 Oct - 19 Oct

includes taxes & fees

9/10 Wonderful! (2,470 reviews)

Comfort Inn & Suites Florence Center Area

527 Woody Jones Blvd Florence SC

฿3,392

฿3,799 total

3 Nov - 4 Nov

includes taxes & fees

9/10 Wonderful! (1,371 reviews)

The Inn at the Crossroads

128 West Main Street Lake City SC

฿3,749

฿4,199 total

11 Nov - 12 Nov

includes taxes & fees

9.4/10 Exceptional! (1,003 reviews)

Frequently asked questions

What's the best place for a stay in Pamplico?

Located 20.9 mi (33.7 km) from the heart of Pamplico, Park Inn by Radisson Florence, SC is a top choice for your stay, based on our traveller data. Two other choices for your visit to the area are Howard Johnson by Wyndham Florence and Quality Inn & Suites Florence Civic Center. See all available top hotels, or vacation rentals in Pamplico.

If I need to cancel my hotel reservation in Pamplico, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Pamplico.

What is staying in Pamplico like?

Visitors will definitely enjoy all that Pamplico has to offer. There are 166 hotels and other accommodation options in the surrounding area. Find out more about Pamplico.

What are the top places to visit in Pamplico?

Places to visit in the wider area include Lions Park, Eastern Carolina Agricultural Fairgrounds and Florence National Cemetery. You'll also find Florence County Museum and Dr. Eddie Floyd Tennis Center in the area. Take a look at what more there is to see and do in Expedia's Pamplico guide.

What's the seasonal weather in Pamplico?

The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 10°C. Average annual precipitation for Pamplico is 1351 mm.

Explore a world of travel with Expedia

More ways to book

Book Hotels in Pamplico on Expedia.com

Find hotels in Pamplico, SC from ฿1,649

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Pamplico

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Pamplico hotels

1. The Inn at the Crossroads

2. Hyatt Place Florence Downtown

3. Quality Inn & Suites Lake City

4. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

5. Days Inn by Wyndham Lake City

6. Comfort Inn & Suites Florence Center Area

7. Fairfield Inn & Suites by Marriott Florence I-20

8. Hotel Florence, Tapestry Collection by Hilton

9. SpringHill Suites by Marriott Florence

10. Homewood Suites by Hilton Florence

11. Park Inn by Radisson Florence, SC

12. Home2 Suites by Hilton Florence, SC

13. TownePlace Suites by Marriott Florence

14. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

15. Staybridge Suites Florence - Civic Center by IHG

16. Howard Johnson by Wyndham Florence

17. Residence Inn Marriott Florence

18. Hampton Inn & Suites Florence Center

19. Hilton Garden Inn Florence

20. Tru by Hilton Florence I-95

Top Pamplico Hotel Reviews

Park Inn by Radisson Florence, SC

The Inn at the Crossroads

Quality Inn & Suites Florence Civic Center

Hyatt Place Florence Downtown

Super 8 by Wyndham Florence

Comfort Inn & Suites Florence Center Area

Howard Johnson by Wyndham Florence

Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

Aloft by Marriott Florence

More cheap stays in Pamplico

Howard Johnson by Wyndham Florence

Days Inn by Wyndham Florence Near Civic Center

Quality Inn & Suites Florence Civic Center

Park Inn by Radisson Florence, SC

Comfort Inn & Suites Florence Center Area

The Inn at the Crossroads

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app