Search Hotels Near Main Street Hyannis, Hyannis

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Check prices for these dates

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20 Dec - 21 Dec
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21 Dec - 22 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Main Street Hyannis hotels

Terrace/patio
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
0.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (1000)
"Staff member Sandy very congenial when we checked in. Laid back atmosphere (early December). Will consider for future Hyannis stay."
United States
Lawrence
The price is ฿4,381
฿5,913 total
includes taxes & fees
21 Dec - 22 Dec
Anchor In Distinctive Waterfront Lodging
Indoor pool, seasonal outdoor pool
Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
3.0 star property
1.9 km from Main Street Hyannis
9.4 out of 10, Exceptional, (97)
"Hotel was quiet and very clean , pool water was cool"
United States
Robyn
The price is ฿3,330
฿3,811 total
includes taxes & fees
21 Dec - 22 Dec
Uncommoner Hotel by Reverie Boutique Collection
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers
Bayside Resort Hotel

Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (1523)
"Reception staff was warm and welcoming! "
United States
Liza
Bayside Resort Hotel
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers
Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
2.5 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (1001)
"Excellent stay."
United States
Patricia
The price is ฿3,544
฿4,057 total
includes taxes & fees
13 Jan - 14 Jan 2026
Hampton Inn & Suites Cape Cod-West Yarmouth
Lobby
Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.5 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (661)
"Excellent staff-clean rooms-great location"
United States
Patrice
The price is ฿3,447
฿3,945 total
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Indoor pool
Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
3.0 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (486)
"Pretty nice location"
United States
Saulius
The price is ฿3,843
฿4,398 total
includes taxes & fees
7 Jan - 8 Jan 2026
Courtyard By Marriott Cape Cod Hyannis
Exterior
Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
1 km from Main Street Hyannis
8.4 out of 10, Very good, (878)
"Nice room, freindly staff. The downside is the food was pricey. "
United States
Steffanie
The price is ฿3,606
฿4,127 total
includes taxes & fees
11 Jan - 12 Jan 2026
Doubletree by Hilton Cape Cod - Hyannis
Exterior
Cape Sands Inn

Cape Sands Inn

Cape Sands Inn
2.5 star property
1.9 km from Main Street Hyannis
8.2 out of 10, Very good, (1016)
"Clean room courteous staff and easy check in "
United States
Linda
The price is ฿2,343
฿2,681 total
includes taxes & fees
21 Dec - 22 Dec
Cape Sands Inn
Exterior
Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
3.0 star property
2.9 km from Main Street Hyannis
8.2 out of 10, Very good, (977)
"Check in was easy and the front desk person was wonderful. "
United States
Anastasios
The price is ฿3,015
฿3,451 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Hyannis by IHG
Free daily continental breakfast
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
2.5 star property
0.3 km from Main Street Hyannis
8.0 out of 10, Very good, (1004)
"Nice hotel had a perfect stay"
United States
David
The price is ฿3,081
฿3,526 total
includes taxes & fees
26 Dec - 27 Dec
Comfort Inn Hyannis - Cape Cod
Front of property
Hyannis Harbor Hotel

Hyannis Harbor Hotel

Hyannis Harbor Hotel
3.5 star property
0.6 km from Main Street Hyannis
8.0 out of 10, Very good, (1000)
"Amazing place "
United States
Mounir
The price is ฿3,924
฿5,760 total
includes taxes & fees
21 Dec - 22 Dec
Hyannis Harbor Hotel
Lobby
Hyannis Plaza Hotel

Hyannis Plaza Hotel

Hyannis Plaza Hotel
2.5 star property
0.9 km from Main Street Hyannis
7.0 out of 10, Good, (970)
"good stay for night"
United States
David
The price is ฿2,286
฿2,931 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hyannis Plaza Hotel
Luxury King Room | Egyptian cotton sheets, premium bedding, individually decorated
Sea Street Inn

Sea Street Inn

Sea Street Inn
4.0 star property
1.5 km from Main Street Hyannis
9.8 out of 10, Exceptional, (45)
"Adrian was an awesome host. Comfortable bed, safe area to walk, beautiful surroundings."
United States
Jori
The price is ฿7,404
฿8,475 total
includes taxes & fees
3 Jan - 4 Jan 2026
Sea Street Inn
Indoor pool
Courtyard Resort

Courtyard Resort

Courtyard Resort
2.0 star property
0.3 km from Main Street Hyannis
8.2 out of 10, Very good, (46)
"Clean and inexpensive"
United States
Robert
The price is ฿3,423
฿3,918 total
includes taxes & fees
4 Jan - 5 Jan 2026
Courtyard Resort
Family House, Private Bathroom, Pool View | Lounge
Sal's Place

Sal's Place

Sal's Place
2.0 star property
2.5 km from Main Street Hyannis
The price is ฿8,794
฿13,834 total
includes taxes & fees
29 Dec - 30 Dec
Sal's Place
Front of property
The Village Inn Cape Cod

The Village Inn Cape Cod

The Village Inn Cape Cod
3.5 star property
6.1 km from Main Street Hyannis
10.0 out of 10, Exceptional, (223)
"It was so charming, would definitely stay there again! "
United States
Kyle
The price is ฿5,308
฿6,075 total
includes taxes & fees
27 Dec - 28 Dec
The Village Inn Cape Cod
Property grounds
The Escape Inn

The Escape Inn

The Escape Inn
2.5 star property
7.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (656)
"clean, convenient and very easy check in/out. "
United States
chris
The price is ฿2,523
฿2,887 total
includes taxes & fees
22 Dec - 23 Dec
The Escape Inn
Terrace/patio
Brewster by the Sea Inn

Brewster by the Sea Inn

Brewster by the Sea Inn
4.0 star property
17.4 km from Main Street Hyannis
9.8 out of 10, Exceptional, (171)
"Brewster By the Sea has it all - great location, amazing innkeeper, unbelievable breakfasts, and great rooms with perfect amenities. "
United States
Donna
The price is ฿9,988
฿11,431 total
includes taxes & fees
3 Jan - 4 Jan 2026
Brewster by the Sea Inn
Gazebo
Veranda Cape Cod Family Resort

Veranda Cape Cod Family Resort

Veranda Cape Cod Family Resort
2.5 star property
7.8 km from Main Street Hyannis
9.2 out of 10, Wonderful, (262)
"Beautiful grounds, quiet and comfortable. Very well run. "
United States
Benita
The price is ฿5,622
฿6,434 total
includes taxes & fees
3 Jan - 4 Jan 2026
Veranda Cape Cod Family Resort
Outdoor pool, pool umbrellas, pool loungers
Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod
4.0 star property
3.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (415)
"The entire place was spotless and rooom beet pleasant. Staff was super friendly and the Landshark Bar was excellent. Highly recommend a stay here ! "
United States
Stephen
The price is ฿4,397
฿6,830 total
includes taxes & fees
21 Dec - 22 Dec
Margaritaville Resort Cape Cod
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Main Street Hyannis Hotel Reviews

Courtyard Resort

Courtyard Resort

10/10 Excellent
"Clean rooms, full kitchens, good area. "
Michael 1-night trip
Posted 3 days ago
Courtyard Resort
Hyannis Host Inn

Hyannis Host Inn

10/10 Excellent
"The air conditioning was working good and the mall was on the same street so it was good "
Yokasta 2-night trip
Posted 3 months ago
Hyannis Host Inn

Hotels near other Main Street Hyannis attractions

John F. Kennedy Hyannis Museum showcases bronze statue and historic architecture in Hyannis Massachusetts

John F. Kennedy Hyannis Museum

4.4/5 (259 reviews)
Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.
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Cape Cod Maritime Museum which includes a bay or harbor and signage

Cape Cod Maritime Museum

You can spend an afternoon studying the exhibits at Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the beautiful beaches in this family-friendly area or visit its seafood restaurants.
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Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, take a look at the 182 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Hyannis Travel Inn is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include Courtyard Resort and Comfort Inn Hyannis - Cape Cod.
How many hotels can I expect to find near Main Street Hyannis?
Expedia has 182 hotels and other accommodation options within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer near Main Street Hyannis.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Whydah Pirate Museum and Cape Cod Maritime Museum feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse and West Parish Meetinghouse are landmarks that you won't want to miss. You can enjoy live performances at Cape Cod Melody Tent and Barnstable Performing Arts Center.