My wife and I just finished a two week Italy vacation at the Hotel Bucintoro in Venice. This is an excellent option for staying in Venice.
The hotel was very clean, quiet, and comfortable. The room had great views of the Lagoon and while located in a quieter part of Venice, it is still walk-able to all the major attractions, shops, and restaurants.
The staff at Hotel Bucintoro was very friendly and helpful in every aspect. Furthermore, the breakfast was extremely good and had a variety of offerings for all tastes. And there's nothing like enjoying a glass of wine on one of their outdoor tables while enjoying the sunset over the lagoon.
It is a small boutique hotel with only a limited number of guests which afforded us lots of privacy and quiet. Overall this is a great hotel option.